Abstract #2121

Monitoring tissue damage during MRgHIFU of bone metastases: relating intra-procedural DWI changes to post-procedural appearances

Sharon L Giles¹, Matthew Brown², Jessica M Winfield¹, David J Collins³, Ian Rivens⁴, John Civale⁴, Gail R ter Haar⁴, and Nandita M deSouza¹

¹CRUK Cancer Imaging Centre, The Royal Marsden Hospital NHS Foundation Trust and The Institute of Cancer Research, London, United Kingdom, ²Anaesthetic Department, The Royal Marsden Hospital NHS Foundation Trust, London, United Kingdom, ³CRUK Cancer Imaging Centre, The Institute of Cancer Research, London, United Kingdom, ⁴Therapeutic Ultrasound, The Institute of Cancer Research, London, United Kingdom

This study assessed intraprocedural DWI for detecting extra- and intra-osseous tissue change during MRgHIFU treatment of bone metastases by comparing appearances with post-procedural and Day-30 DWI and T1-W contrast-enhanced image appearances. Change in image appearances for n=9 patients was assessed by 2 observers assigning a consensus score where 0=no, 1=mild, 2=moderate and 3=striking change. Extra-osseous DWI changes were more conspicuous than intra-osseous DWI changes, but were less striking than immediate post-procedural contrast-enhanced changes. However, intra-procedural DWI changes significantly correlated with post-procedural and Day-30 DWI and contrast-enhanced changes, suggesting that intra-procedural DWI can provide an indicator of subsequent extra-osseous tissue damage.

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