Abstract #2122

Response of MR Contrast Parameters in Tissues and Tissue Mimicking Phantoms to Histotripsy

Steven P Allen¹, Luis Hernandez-Garcia², Charles A Cain¹, and Timothy L Hall¹

¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States, ²fMRI Lab, University of Michigan, Ann Arbor, MI, United States

We estimate the R2 relaxation rate and the apparent diffusion coefficient at 7T in a variety of in vitro tissues and tissue mimicking phantoms after they have been subjected to homogenization by ultrasonic cavitation (histotripsy). The estimated R2 rate of these lesions decreases with increased treatment so long as the lesions are made in materials with high iron content. When lesions are made in brain tissue or phantoms with low iron content, the R2 rate remains unperturbed by homogenization. The apparent diffusion coefficient increases with increasing treatment for all tissues and phantoms.

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