Abstract #2338

Pool size effects in experiments with hyperpolarized [13C]ketobutyrate

Cornelius von Morze¹, Peder E Larson¹, Michael A Ohliger¹, Ralph E Hurd², John Kurhanewicz¹, and Daniel B Vigneron¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, ²GE Healthcare, Menlo Park, CA, United States

The purpose of this abstract was to investigate pool size effects in experiments with hyperpolarized [¹³C]α-ketobutyrate (αKB), a molecular analog of pyruvate which also has substantial activity with LDH. In contrast to pyruvate, formation of the reduction product [¹³C]α-hydroxybutyrate (αHB) necessarily reflects net metabolic flux as opposed to label exchange. We observed little change when co-injecting αHB but a large increase in the αHB-to-αKB ratio when co-injecting lactate. This suggests that the observed conversion of αKB to αHB only reflects net metabolic flux even in the presence of a large pool of reduction product.

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