Abstract #2339

Feasibility of sensing small molecule thiols using hyperpolarized [13C]cyanate

Cornelius von Morze¹, Chloe Najac¹, Robert R Flavell¹, David E Korenchan¹, Pavithra Viswanath¹, Lucas Carvajal¹, John Kurhanewicz¹, Sabrina M Ronen¹, Daniel B Vigneron¹, and David M Wilson¹

¹Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States

The purpose of this study was to show basic feasibility of non-invasively detecting small molecule thiols using hyperpolarized [¹³C]cyanate. We detected rapid formation of the expected hyperpolarized S-[¹³C]carbamyl thiol adduct after adding cysteine to liquid hyperpolarized [¹³C]cyanate samples. This work demonstrates a new non-enzymatic approach for detecting small molecule thiols such as reduced glutathione, which could be very useful for research on oxidative stress.

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