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Abstract #2347

Robust, Quantitative Methods Applied to Clinical Hyperpolarized C-13 MR of Prostate Cancer Patients

Peder Eric Zufall Larson1, Jeremy Gordon1, John Maidens2, Murat Arcak2, Hsin-Yu Chen1, Galen Reed1, Ilwoo Park1, Rahul Aggarwal3, Robert Bok1, Sarah J Nelson1, John Kurhanewicz1, and Daniel B Vigneron1

1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, 2Electrical Engineering & Computer Sciences, University of California - Berkeley, Berkeley, CA, United States, 3Medicine, University of California - San Francisco, San Francisco, CA, United States

Clinical evaluation of metabolic MRI using hyperpolarized C-13 agents has begun in earnest at multiple sites with the availability of the SpinLab commercial polarizer. For this technology to succeed, robust imaging and analysis methods for quantification of metabolic activity are required. We have developed and are applying efficient dynamic imaging methods, robust kinetic models, and specialized calibration schemes to enable accurate and reproducible quantification in clinical hyperpolarized MR studies.

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