Peder Eric Zufall Larson1, Jeremy Gordon1, John Maidens2, Murat Arcak2, Hsin-Yu Chen1, Galen Reed1, Ilwoo Park1, Rahul Aggarwal3, Robert Bok1, Sarah J Nelson1, John Kurhanewicz1, and Daniel B Vigneron1
1Radiology and Biomedical Imaging, University of California - San Francisco, San Francisco, CA, United States, 2Electrical Engineering & Computer Sciences, University of California - Berkeley, Berkeley, CA, United States, 3Medicine, University of California - San Francisco, San Francisco, CA, United States
Clinical evaluation of metabolic MRI using hyperpolarized
C-13 agents has begun in earnest at multiple sites with the availability of the
SpinLab commercial polarizer. For this
technology to succeed, robust imaging and analysis methods for quantification
of metabolic activity are required. We
have developed and are applying efficient dynamic imaging methods, robust
kinetic models, and specialized calibration schemes to enable accurate and
reproducible quantification in clinical hyperpolarized MR studies.
