Abstract #2348

A Molecular Imaging Approach to Mercury Sensing Based on Hyperpolarized 129Xe Molecular Clamp Probe

Qianni Guo¹, Qingbin Zeng¹, Weiping Jiang¹, Xiaoxiao Zhang¹, Qing Luo¹, and Xin Zhou¹

¹Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of

Mercury contamination is widespread and arises from a variety of natural sources.We propose the use of hyperpolarized ¹²⁹Xe nuclear magnetic resonance (NMR) spectroscopy for the sensitive detection of Hg²⁺ ions in aqueous solution.We develop a biosensor whose molecular structure is like a clamp. When interact with Hg²⁺ in aqueous solution, the molecular structure of the biosensor could be changed as a clamp from “open” to “closed”. This molecular structure change causes the distance between the two cryptophane cages of the biosensor become closer, and the electron cloud of them overlapped. As a result, comparing with normal downfield chemical shifts of the reported xenon biosensors formetallic ions, the Xe caged in the cryptophane moiety shows a upfield chemical shift change from 66.5 ppm to 66.1 ppm. Images were obtained using a CSI method preciously used for clinical MRI.

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