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Abstract #2470

Amide proton transfer (APT) Imaging in Head and Neck Cancer: preliminary results

Benjamin King Hong Law1, Ann D King1, Kunwar S Bhatia1, Anil T Ahuja1, Brigette B Ma2, David Ka-Wai Yeung2, Yi-Xiang Wang1, and Jing Yuan3

1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, Hong Kong, 2Department of Clinical Oncology, The Chinese University of Hong Kong, Shatin, Hong Kong, 3Medical Physics and Research Department, Hong Kong Sanatorium & Hospital, Happy Valley, Hong Kong

Amide proton transfer (APT) imaging is a promising functional MRI technique that investigates the chemical exchange processes between free water and mobile amide protons in cancers. It is sensitive to small variations in these amide protons but the potential value of APT imaging in head and neck cancer is unknown. We have shown APT imaging of head and neck cancer is feasible, although the success rate varies with tumour site. No difference was found between the APT parameters of undifferentiated nasopharyngeal carcinoma and head and neck squamous cell carcinoma in this small preliminary study, but larger studies are needed.

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