Dattesh D Shanbhag1, Parita Sanghani1, Reem Bedair 2, Venkata Veerendranadh Chebrolu1, Uday Patil1, Sandeep N Gupta3, Scott Reid 4, Fiona Gilbert 2, Andrew Patterson 2, Rakesh Mullick1, and Martin Graves2
1GE Global Research, Bangalore, India, 2University of Cambridge, Cambridge, United Kingdom, 3GE Global Research, Niskayuna, NY, United States, 4GE Healthcare, Leeds, United Kingdom
In DCE-MRI, T1 map is necessary for signal to concentration
conversion. In highly fat-water mixed tissue such as breast, contrast uptake
primarily changes T1 values of water protons. Therefore, DCE quantification in
breast cancer must reliably measure water T1. We evaluated T1 maps
obtained using Dixon based fat-water separated VFA method and compared values
in fat, fibro-glandular tissue and tumors. We observed that T1 mapping with Dixon
based VFA method and non-linear fitting recovers T1 values for
tissue in breast by reducing partial volume. We conclude that water only T1
mapping will improve accuracy of PK modeling in breast cancer.
