Abstract #2732

Dixon fat-water imaging based variable flip-angle T1 mapping quantification for breast cancer

Dattesh D Shanbhag¹, Parita Sanghani¹, Reem Bedair ², Venkata Veerendranadh Chebrolu¹, Uday Patil¹, Sandeep N Gupta³, Scott Reid ⁴, Fiona Gilbert ², Andrew Patterson ², Rakesh Mullick¹, and Martin Graves²

¹GE Global Research, Bangalore, India, ²University of Cambridge, Cambridge, United Kingdom, ³GE Global Research, Niskayuna, NY, United States, ⁴GE Healthcare, Leeds, United Kingdom

In DCE-MRI, T₁ map is necessary for signal to concentration conversion. In highly fat-water mixed tissue such as breast, contrast uptake primarily changes T₁values of water protons. Therefore, DCE quantification in breast cancer must reliably measure water T₁. We evaluated T₁ maps obtained using Dixon based fat-water separated VFA method and compared values in fat, fibro-glandular tissue and tumors. We observed that T₁ mapping with Dixon based VFA method and non-linear fitting recovers T₁ values for tissue in breast by reducing partial volume. We conclude that water only T1 mapping will improve accuracy of PK modeling in breast cancer.

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