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Abstract #2732

Dixon fat-water imaging based variable flip-angle T1 mapping quantification for breast cancer

Dattesh D Shanbhag1, Parita Sanghani1, Reem Bedair 2, Venkata Veerendranadh Chebrolu1, Uday Patil1, Sandeep N Gupta3, Scott Reid 4, Fiona Gilbert 2, Andrew Patterson 2, Rakesh Mullick1, and Martin Graves2

1GE Global Research, Bangalore, India, 2University of Cambridge, Cambridge, United Kingdom, 3GE Global Research, Niskayuna, NY, United States, 4GE Healthcare, Leeds, United Kingdom

In DCE-MRI, T1 map is necessary for signal to concentration conversion. In highly fat-water mixed tissue such as breast, contrast uptake primarily changes T1 values of water protons. Therefore, DCE quantification in breast cancer must reliably measure water T1. We evaluated T1 maps obtained using Dixon based fat-water separated VFA method and compared values in fat, fibro-glandular tissue and tumors. We observed that T1 mapping with Dixon based VFA method and non-linear fitting recovers T1 values for tissue in breast by reducing partial volume. We conclude that water only T1 mapping will improve accuracy of PK modeling in breast cancer.

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