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Abstract #2818

Rapid Multislice T1 Mapping of Contrast-Enhanced Mouse Tumor Using Saturation Recovery Look-Locker Method with Spiral Readout

Yuchi Liu1, Zheng Han1, Kai Jiang2, Yun Jiang1, Yajuan Li1, Zheng-Rong Lu1, and Xin Yu1,3,4,5

1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, United States, 3Radiology, Case Western Reserve University, Cleveland, OH, United States, 4Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, United States, 5Case Center for Imaging Research, Case Western Reserve University, Cleveland, OH, United States

In this study, a rapid multislice saturation-recovery Look-Locker (MSRLL) T1 mapping method with spiral readout was developed for the application on tissues with long T1 value, such as tumor. This method was validated in vitro and evaluated in a dynamic contrast-enhanced MRI (DCE-MRI) study on mouse tumor. The spiral MSRLL method showed a strong agreement with Cartesian method, and achieved temporal resolution of 2 min 40s with a voxel size of 0.23×0.23×1 mm3 in vivo.

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