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Abstract #2837

Myelin Water Imaging in Multiple Sclerosis Post-Mortem Spinal Cord

Amy McDowell1, Natalia Petrova1, Irene Vavasour2, David Thomas3, Daniele Carassiti1, Marc Miquel4, Shannon Kolind2, and Klaus Schmierer1,5

1Neuroscience and Trauma, Queen Mary University of London, London, United Kingdom, 2University of British Columbia, Division of Neurology, Department of Medicine, Vancouver, BC, Canada, 3Neuroimaging Analysis Centre, Department of Brain Repair and Rehabilitation, London, United Kingdom, 4Clinical Physics, Barts Health Trust, London, United Kingdom, 5Department of Neurology, Barts Health Trust, London, United Kingdom

Evidence obtained from post mortem multiple sclerosis (MS) brain suggest that ‘myelin water fraction’ (MWF) acquired using the CPMG sequence is strongly associated with myelin. However, relaxation times differ significantly between brain and spinal cord (SC), a key area of the clinical manifestations of MS. We investigated the histological correlates of MWF in post mortem MSSC. Good separation of the short T2 components, and correlation between MWF and myelin content detected using immunohistochemistry were observed.

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