Abstract #2837

Myelin Water Imaging in Multiple Sclerosis Post-Mortem Spinal Cord

Amy McDowell¹, Natalia Petrova¹, Irene Vavasour², David Thomas³, Daniele Carassiti¹, Marc Miquel⁴, Shannon Kolind², and Klaus Schmierer^1,5

¹Neuroscience and Trauma, Queen Mary University of London, London, United Kingdom, ²University of British Columbia, Division of Neurology, Department of Medicine, Vancouver, BC, Canada, ³Neuroimaging Analysis Centre, Department of Brain Repair and Rehabilitation, London, United Kingdom, ⁴Clinical Physics, Barts Health Trust, London, United Kingdom, ⁵Department of Neurology, Barts Health Trust, London, United Kingdom

Evidence obtained from post mortem multiple sclerosis (MS) brain suggest that ‘myelin water fraction’ (MWF) acquired using the CPMG sequence is strongly associated with myelin. However, relaxation times differ significantly between brain and spinal cord (SC), a key area of the clinical manifestations of MS. We investigated the histological correlates of MWF in post mortem MSSC. Good separation of the short T₂ components, and correlation between MWF and myelin content detected using immunohistochemistry were observed.

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