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Abstract #2838

Linear models for estimating myelin and iron content in the brain

Riccardo Metere1 and Harald E. Möller1

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

Quantitative MRI maps are believed to strongly correlate with myelin and and ferritin content. Recently, a model combining prior information from non-MRI quantitative techniques was proposed for the quantification of myelin and ferritin based on relaxometry information $$$R_1$$$ and $$$R_2^*$$$ in post mortem human brain samples. Here, we propose four different simple linear models for tentatively obtaining semi-quantitative information using simultaneous quantitative acquisitions under in vivo conditions. Three of the four model are relatively consistent, but do not agree with previously published measurements. A fourth model, although not validated, is compatible with previous works.

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