Abstract #2840

Absolute quantification of white matter lesion iron and myelin using QSM and FAST-T2 at 3 Tesla

Thanh D. Nguyen¹, Pascal Spincemaille¹, Sneha Pandya¹, Susan A. Gauthier¹, and Yi Wang¹

¹Weill Cornell Medical College, New York, NY, United States

The purpose of this study was to develop a clinically feasible method for quantifying myelin and iron distribution in white matter lesions by integrating absolute myelin water mapping using Fast Acquisition using Spiral Trajectory and T2prep (FAST-T2) sequence with Quantitative Susceptibility Mapping (QSM). Preliminary results from 8 healthy volunteers and 3 MS patients demonstrated the feasibility of the developed method.

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