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Abstract #2840

Absolute quantification of white matter lesion iron and myelin using QSM and FAST-T2 at 3 Tesla

Thanh D. Nguyen1, Pascal Spincemaille1, Sneha Pandya1, Susan A. Gauthier1, and Yi Wang1

1Weill Cornell Medical College, New York, NY, United States

The purpose of this study was to develop a clinically feasible method for quantifying myelin and iron distribution in white matter lesions by integrating absolute myelin water mapping using Fast Acquisition using Spiral Trajectory and T2prep (FAST-T2) sequence with Quantitative Susceptibility Mapping (QSM). Preliminary results from 8 healthy volunteers and 3 MS patients demonstrated the feasibility of the developed method.

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