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Abstract #3015

Between-Session Variability of Diffusion Kurtosis Metrics in in vivo Brains

Nino Kobalia1, Farida Grinberg1,2, Ezequiel Farrher1, Xiang Gao1, and N. Jon Shah1,2

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Jülich GmbH, Jülich, Germany, 2Department of Neurology, Faculty of Medicine, JARA, RWTH Aachen University, Aachen, Germany

The knowledge of intra- and inter-subject variability of diffusion kurtosis imaging metrics plays an important role in the interpretation of the results in clinical trials. However, it has not been sufficiently studied thus far. The purpose of this work is to investigate between-session variability of a single subject with N-repeated measurements with an identical experimental protocol, and thus to provide the baseline for comparison with phantom measurements and inter-subject in vivo variability. We quantified variability in terms of the coefficient of variation and studied how its value varies between various diffusion tensor and kurtosis metrics estimated in twenty anatomical regions.

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