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Abstract #3016

The importance of b-values selection and the precision of diffusion kurtosis estimation by the conventional schemes

Andrey Chuhutin1, Noam Shemesh2, Brian Hansen1, and Sune Nørhøj Jespersen1,3

1CFIN, Aarhus University, Aarhus, Denmark, 2Champalimaud Neuroscience Programme, Champalimaud Centre for the Unknown, Lisbon, Portugal, 3Department of Physics and Astronomy, Aarhus University, Aarhus, Denmark

In DKI imaging studies, a wide range of different gradient strengths is used, which is known to affect the estimated kurtosis. Being driven by a need to assess the validity of the DKI expression and the accuracy of the estimated parameters as a function of b-value we both evaluated the variability of the kurtosis parameter for the in vivo and ex vivo data for different fitting techniques and studied the error in a mean kurtosis parameter with respect to the ground truth. The results and conclusions suggest circumspection while preferring a specific technique.

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