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Abstract #3097

White Matter Asymmetry During Development Using Diffusion Kurtosis Imaging

Xiang Gao1, Farida Grinberg1,2, Ezequiel Farrher1, Fei Li1, Eileen Oberwelland3,4, Irene Neuner1,5,6, Kerstin Konrad4,6,7, and N.Jon. Shah1,2,6

1Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany, 2Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, 3Translational Brain Research in Psychiatry and Neurology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany, 4Institute of Neuroscience and Medicine - 3, Forschungszentrum Juelich GmbH, Juelich, Germany, 5Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, 6JARA - BRAIN, Translational Medicine, Juelich, Germany, 7Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany

We compare changes in the white matter asymmetry index in conventional fractional anisotropy (FA) and other diffusion kurtosis imaging (DKI) metrics in adults and children. For some fibres, such as cingulate gyrus, hippocampus and superior longitudinal fasciculus, other DKI parameters show significant asymmetry where FA fails. When compared to adults, children showed more laterality in cingulate gyrus, superior longitudinal fasciculus and superior longitudinal fasciculus in temporal parts, which indicate that the degree of asymmetry in these fibres is higher during childhood.

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