Abstract #3097

White Matter Asymmetry During Development Using Diffusion Kurtosis Imaging

Xiang Gao¹, Farida Grinberg^1,2, Ezequiel Farrher¹, Fei Li¹, Eileen Oberwelland^3,4, Irene Neuner^1,5,6, Kerstin Konrad^4,6,7, and N.Jon. Shah^1,2,6

¹Institute of Neuroscience and Medicine - 4, Forschungszentrum Juelich GmbH, Juelich, Germany, ²Department of Neurology, Faculty of Medicine, RWTH Aachen University, Aachen, Germany, ³Translational Brain Research in Psychiatry and Neurology, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany, ⁴Institute of Neuroscience and Medicine - 3, Forschungszentrum Juelich GmbH, Juelich, Germany, ⁵Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ⁶JARA - BRAIN, Translational Medicine, Juelich, Germany, ⁷Child Neuropsychology Section, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany

We compare changes in the white matter asymmetry index in conventional fractional anisotropy (FA) and other diffusion kurtosis imaging (DKI) metrics in adults and children. For some fibres, such as cingulate gyrus, hippocampus and superior longitudinal fasciculus, other DKI parameters show significant asymmetry where FA fails. When compared to adults, children showed more laterality in cingulate gyrus, superior longitudinal fasciculus and superior longitudinal fasciculus in temporal parts, which indicate that the degree of asymmetry in these fibres is higher during childhood.

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