Accurate and precise mapping of metabolically active eloquent foci in the brain, differentiating recurrent neoplasm from pseudo-progression, differentiating tumefactive demyelination from neoplasm, delineating the actual stroke penumbra, and early detection of neurodegenerative disease, all require high-resolution imaging of underlying relative brain oxygen metabolism. At the present time, however, there is no robust technique that can map brain metabolism at a high spatiotemporal resolution. This work derives and demonstrates a model for imaging of relative CMRO2 with T1ρ-weighted MRI which can be readily performed on any clinical MRI scanner with a simple pulse sequence and without the need for hardware modification. This novel approach is optimized to yield a spatial resolution of 0.2 mm3 and temporal resolution of 3.2 sec, and developed to work without exogenous tracer or contrast agent administration, blood sampling, or statistical parametrization of the image data.
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