Abstract #3335

Quantifying cerebral blood flow with distortion-corrected pseudo-continuous arterial spin labeling

Michael N Hoff¹, Swati R Levendovszky¹, and Jalal B Andre¹

¹Radiology, University of Washington, Seattle, WA, United States

Cerebral blood flow (CBF) may be quantified using pseudo-continuous arterial spin labeling (pCASL), but pCASL suffers from image distortion due to its long echo planar imaging (EPI) readout. Phase labeling for additional coordinate encoding (PLACE) is employed here to remove distortion. EPI images and pCASL subtraction images show improved spatial accuracy when compared to a T1-weighted, anatomical reference image. This results in improved accuracy in CBF quantification, which could potentially improve the assessment of disease-specific patterns indicated by regional CBF abnormalities.

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