Abstract #3681

Time-course metabolic changes in high-fat diet-induced obesity in rats: hyperpolarized 13C MRS

Gwang-Woo Jeong^1,2, Chang-Hyun Oh³, Gwang-Won Kim², Chung-Man Moon², Xiao-Li Song¹, Yun-Hyeon Kim¹, Kyu-Youn Ahn⁴, and Heoung-Keun Kang¹

¹Department of Radiology, Chonnam National University Medical School, Gwang-ju, Korea, Republic of, ²Research Institute of Medical Imaging, Chonnam National University Medical School, Gwang-ju, Korea, Republic of, ³Department of Electronics and Information Engineering, Korea University, Gwang-ju, Korea, Republic of, ⁴Department of Anatomy, Chonnam National University Medical School, Gwang-ju, Korea, Republic of

Non-alcoholic fatty liver is an increasing common liver disease in world population. Recent hyperpolarized 13C magnetic resonance spectroscopy (HP 13C MRS) studies revealed the cellular metabolite changes associated with the various liver diseases in animals. However, a study for high-fat diet(HFD)-induced obesity using HP 13C MRS in animal model has not yet been performed until now. The purpose of this study was to investigate the time-course metabolic changes based on HP 13C MRS in HFD-induced obesity in rats and their correlations with serum enzyme levels.

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