Abstract #3682

Noninvasive biomarkers for the diagnosis of hepatic ischemia reperfusion injury: A real-time in vivo hyperpolarized 13C MRS and IVIM-DWI

Chung-Man Moon¹, Gwang-Won Kim¹, Heoung-Keun Kang², Yun-Hyeon Kim², Kyu-Youn Ahn³, and Gwang-Woo Jeong^1,2

¹Research Institute for Medical Imaging, Chonnam National University Hospital, Gwangju, Korea, Republic of, ²Radiology, Chonnam Natioanl University Medical School, Gwangju, Korea, Republic of, ³Anatomy, Chonnam Natioanl University Medical School, Gwangju, Korea, Republic of

Hepatic ischemia reperfusion injury (IRI) induces cellular damage and causes cell death. It can lead to acute liver failure accompanied with biochemical changes, microcirculatory disturbances and/or histopathologic changes. Early detection of impaired liver function is vital for effective therapeutic interventions and thus prevents its progression to liver failure. However, an in vivo study of hepatic IRI model in combination with hyperpolarized ¹³C magnetic resonance spectroscopy (¹³C MRS) and diffusion-weighted imaging (DWI) has not yet been attempted until now. The purpose of this study was to investigate the cellular metabolite change, diffusion of water molecules and microcirculation of blood in rat model with hepatic IRI and their correlations with enzyme levels.

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