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Abstract #3854

A prospective study comparing R2* derived Liver iron concentration(LIC) with noise-corrected post processing of data against FerriScan reported LIC in patients with liver iron overload.

Kartik Jhaveri1, Stephan Kannengiesser2, Nima Sadougi3, Marshall Sussman1, Hooman Hosseini-Nik3, Leila Zahedi3, and Richard Ward1

1UHN,University of Toronto, Toronto, ON, Canada, 2Siemens Germany, Erlangen, Germany, 3UHN, Toronto, ON, Canada

MRI is currently utilised as a non-invasive method for liver iron concentration (LIC) estimation and has essentially replaced liver biopsy. FerriScan derived LIC is considered the “gold standard” but has associated increased costs and delay results from required external data transmittal. There is no universal agreement or standardization of R2* derived LIC methods. We describe an optimized R2* method with noise corrected post processing of data for LIC estimation with simultaneous comparison to FerriScan derived LIC. Our results show very good correlation between R2* LIC and FerriScan LIC with potential for substitution of the latter with our R2* technique.

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