Abstract #3944

31P MR Imaging and Concentration Measurements

Arthur Coste¹, Alexandre Vignaud¹, Philippe Ciuciu^1,2, Fawzi Boumezbeur¹, Franck Mauconduit³, Alexis Amadon¹, Sandro Romanzetti⁴, Denis Le Bihan¹, and Cécile Lerman¹

¹MR Imaging and Spectroscopy Unit, NeuroSpin, Gif sur Yvette, France, ²Parietal, INRIA Saclay, Saclay, France, ³Siemens Healthcare, Saint Denis, France, ⁴University Clinic RWTH Aachen, Aachen, Germany

This work describes a novel method accounting for MR acquisition properties (B₀, B₁⁺,B₁^-,T₁,T₂*) to perform concentration measurements in the framework of in vitro Phosphorus MRI. Our pipeline uses a non-Cartesian 3D sequence for efficient signal sampling and a wavelet regularized least square method for reconstruction. We demonstrated within an acceptable time for human experiment, for 5mm isotropic resolution, that we are able to calibrate and measure absolute ³¹P concentrations.

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