Abstract #3950

Accelerated Five-Dimensional Echo Planer J-resolved spectroscopic imaging: Pilot findings in untreated and CPAP treated Obstructive Sleep Apnea

Manoj Kumar Sarma¹, Paul Michael Macey², Zohaib Iqbal¹, Rajakumar Nagarajan¹, Ravi Aysola³, and M. Albert Thomas¹

¹Radiological Sciences, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States, ²School of Nursing, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States, ³Division of Pulmonary and Critical Care Medicine, UCLA School of Medicine, Los angeles, Los Angeles, CA, United States

With the rise of people with obesity and older age, obstructive sleep apnea (OSA) has become a potentially disabling health problem. Continuous positive airway pressure (CPAP) is the most common treatment method for OSA patients. Here we examined neurochemical changes of untreated and CPAP treated OSA patients versus healthy controls in several brain region including parietal gray/white, insular cortex and frontal gray/white regions to demonstrate the nature of tissue changes using an accelerated five-dimensional (5D) echo-planar J-resolved spectroscopic imaging (EP-JRESI) sequence. We observed statistically significant differences between OSA patients and healthy control subjects in the occipital gray NAA/Cr, frontal gray Ch/Cr and mI/Cr, and occipital white Ch/Cr regions. Most of the differences were seen to be reversed in the OSA patients’ with CPAP cohort except that the differences in occipital gray NAA/Ch and frontal gray mI/Cr remained significance. To validate our findings, further longitudinal studies using a large cohort of OSA subjects before and after CPAP are required. These pilot findings demonstrate that the 5D EP-JRESI sequence can be easily combined with any MRI protocol.

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