Abstract #3992

Echo-time optimization for J-difference editing of glutathione at 3T

Kimberly L Chan^1,2,3, Nicolaas AJ Puts^2,3, Karim Snoussi^2,3, Ashley D Harris^2,3,4,5,6, Peter B Barker^2,3, and Richard AE Edden^2,3

¹Biomedical Engineering, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Radiology and Radiological Science, Johns Hopkins School of Medicine, Baltimore, MD, United States, ³F.M. Kirby Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Radiology, University of Calgary, Calgary, AB, Canada, ⁵Hotchkiss Brain Institute and Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁶CAIR Program, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada

Glutathione is involved in maintaining redox balance, and can be detected in vivo in brain tissue using MEGA-PRESS editing. In literature to-date, echo times from 68 to 131 ms have been stated as optimal; in this abstract, the TE-dependence of MEGA-edited GSH signals is investigated using simulations, and phantom and in vivo experiments. It is shown that, in vivo, there is a moderate (15%) benefit of detecting GSH at TE 120 ms over 68 ms. We also demonstrate that the longer echo time allows the use of higher-bandwidth, more rectangular slice-selective refocusing pulses, giving a further 57% gain in signal.

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