Abstract #4165

Assessment of chemotherapy-induced brain volume and shape changes in breast cancer patients using voxel-based morphometry and vertex-wise shape analysis

Ren-Horng Wang¹, Vincent Chin-Hung Chen², Dah-Cherng Yeh³, and Jun-Cheng Weng^1,4

¹Department of Medical Imaging and Radiological Sciences, Chung Shan Medical University, Taichung, Taiwan, ²Department of Psychiatry, Chang Gung Memorial Hospital, Chiayi, Taiwan, ³Department of Breast Surgery, Taichung Veterans General Hospital, Taichung, Taiwan, ⁴Department of Medical Imaging, Chung Shan Medical University Hospital, Taichung, Taiwan

Recent advances in breast cancer treatment have improved the long-term survival rate in cancer patients. The success in primary breast cancer treatment marks the importance of the post-treatment care. Cancer-related trauma after chemotherapy have been widely reported by breast cancer survivors. Previous study showed the decreased gray matter volume one month after chemotherapy completion, especially in frontal regions which is known for cognitive function. Another study indicated that there is reduction in cerebellar regions and right thalamus after the chemotherapy. However, several studies focused on the change of brain volume, but did not mention about the change of brain shape. Thus, in the study we aim to find out the differences of both brain volume and shape between chemotherapy-treated breast cancer patients and healthy subjects based on voxel-based morphometry (VBM) and vertex-wise shape analysis, respectively. In our results, reduced gray matter volume of right thalamus and white matter volume of cerebellum, and altered shape of left amygdala, bilateral thalamus, and bilateral hippocampus was found in the chemotherapy-treated breast cancer patients compared to normal controls.

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