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Abstract #4383

Evaluation of perfusion and hypoxia parameters in healthy subjects and patients with high-grade carotid artery stenosis

Stephan Kaczmarz1, Jens Göttler1, Anne Kluge1, Dimitrios C. Karampinos2, Claus Zimmer1, and Christine Preibisch1,3

1Department of Neuroradiology, Technische Universität München, Munich, Germany, 2Department of Radiology, Technische Universität München, Munich, Germany, 3Clinic for Neurology, Technische Universität München, Munich, Germany

Severe intracranial arterial stenosis (SIAS) is a major health issue as it often accounts for strokes. Here, we present preliminary data from a clinical study in patients with SIAS compared to healthy controls. The major aim was to evaluate the reliability of perfusion and oxygenation related measures by analyzing their hemispheric symmetry to assess their potential diagnostic capabilities. Preliminary results imply symmetry of all measures between hemispheres of healthy controls. Regarding patients, only pCASL-based CBF implies a reduced perfusion on the side of carotid artery stenosis which is in accordance to recent literature and is currently under further investigation.

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