Meeting Banner
Abstract #4384

Arterial Spin Labeling MRI Evaluation of Cerebrovascular Reserve with Acetazolamide in Patients with Sickle Cell Disease

Lena Václavů1, Henk Mutsaerts2, Pim van Ooij1, Bart J Biemond3, John C Wood4, Charles BLM Majoie1, Ed van Bavel5, and Aart J Nederveen1

1Radiology, Academic Medical Center, Amsterdam, Netherlands, 2Sunnybrook Research Institute, Toronto, ON, Canada, 3Internal Medicine, Academic Medical Center, Amsterdam, Netherlands, 4Cardiology, Children's Hospital Los Angeles, Los Angeles, CA, United States, 5Biomedical Engineering and Physics, Academic Medical Center, Amsterdam, Netherlands

Arterial spin labelling perfusion MRI was employed with an acetazolamide challenge to probe the cerebrovascular physiology in patients with sickle cell disease and matched controls. Cerebral blood flow was estimated at baseline and cerebrovascular reserve(CVR) was calculated after vasodilation with acetazolamide. We found that patients had limited CVR compared to controls, and that the patients with the highest CBF at baseline also had the smallest response to acetazolamide. ASL-based CBF measurements with ACZ showed robust CVR results indicating the cerebral hemodynamics of some patients may be impaired.

This abstract and the presentation materials are available to members only; a login is required.

Join Here