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Abstract #4419

Absolute metabolite concentration of Creatine in the deep gray matter measured using short echo 1H-MRS predict long-term prognosis of neonatal hypoxic-ischemic encephalopathy as excellent as NAA concentration

Noriko Aida1,2, Jun Shibasaki3, Moyoko Tomiyasu1,2, Yuri Nishi1,4, Naho Morisaki4, Takeo Fujiwara4, Katsuaki Toyoshima3, and Takayuki Obata2

1Radiology, Kanagawa Children's Medical Center, Yokohama, Japan, 2Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan, 3Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan, 4Social Medicine, National Research Institute for Child Health and Development, Tokyo, Japan

Absolute metabolite concentrations of N-acethylaspartate (NAA), Choline(Cho) and Creatine(Cr) in the deep gray matter of 44 near term neonates with hypoxic-ischemic encephalopathy (HIE), measured using PRESS method short echo 1H-MRS within 2 weeks after birth, showed excellent prognostic values (AUC; NAA: 0.98, Cho: 0.96, Cr: 0.99) with the adverse outcomes having significantly lower measurements compared to those with favorable outcomes, while Lactate was less efficient (AUC 0.74). Moreover NAA and Cr concentrations measured at 24-96 hours revealed perfect prognostic values (AUC 1.00). Early measurement of absolute Cr and NAA concentrations can be excellent biomarkers of infants suffered with neonatal HIE.

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