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Abstract #4420

Iron deposition in theĀ globus pallidus of healthy youth

Karthik Prabhakaran1, David Roalf1, Mark Elliott1, Simon Vandekar1, Kosha Ruparel1, Ryan Hopson1, Efstathios D Gennatas1, Jeffrey Valdez1, Chad Jackson1, Theodore Satterthwaite1, Raquel Gur1, and Ruben Gur1

1University of Pennsylvania, Philadelphia, PA, United States

R2*, the transverse relaxation rate was used to measure iron deposition in the globus pallidus of 815 youth and young adults between the ages of 8 and 22. Significant iron deposition occurs in the globus pallidus between the ages of 8 and 22 in accordance with previously described models of iron deposition in the brain throughout the lifespan. Among adolescents (age 12-16) females had lower iron deposition in the globus pallidus (p < 0.001) as compared to males, this may be related to adolescent females being especially susceptible to dietary iron deficiency because of poor dietary intake in conjunction with high iron requirements related to rapid growth and menstrual blood loss.

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