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Abstract #4421

Parcellation of neonatal brain MRI into 107 regions using atlas propagation through intermediate time points in childhood.

Manuel Blesa1, Ahmed Serag1, Alaistir G Wilkinson2, Devasuda Anblagan1,3, Emma J Telford1, Rozalia Pataki1, Sarah A Sparrow1, Gillian Macnaught4, Scott I Semple4, Mark E Bastin3, and James P Boardman1,3

1MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom, 2Department of Radiology, Royal Hospital for Sick Children, Edinburgh, United Kingdom, 3Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 4Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom

We created a neonatal brain atlas of healthy subjects that can be applied to multi-modal MRI data. Structural and diffusion 3T MRI scans were acquired after birth from 25 neonates born at term. The SRI24/TZO atlas was propagated to the neonatal data using temporal registration via childhood templates (NIHPD), with the final atlas (the Edinburgh Neonatal Atlas, ENA25) constructed using iterative averaging of T1-weighted volumes. The computed transformations were applied to T2-weighted data, diffusion maps and tissue probability maps to provide a multi-modal atlas with 107 anatomical regions; and we have generated a symmetric version to facilitate studies of laterality.

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