Abstract #4421

Parcellation of neonatal brain MRI into 107 regions using atlas propagation through intermediate time points in childhood.

Manuel Blesa¹, Ahmed Serag¹, Alaistir G Wilkinson², Devasuda Anblagan^1,3, Emma J Telford¹, Rozalia Pataki¹, Sarah A Sparrow¹, Gillian Macnaught⁴, Scott I Semple⁴, Mark E Bastin³, and James P Boardman^1,3

¹MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom, ²Department of Radiology, Royal Hospital for Sick Children, Edinburgh, United Kingdom, ³Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ⁴Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, United Kingdom

We created a neonatal brain atlas of healthy subjects that can be applied to multi-modal MRI data. Structural and diffusion 3T MRI scans were acquired after birth from 25 neonates born at term. The SRI24/TZO atlas was propagated to the neonatal data using temporal registration via childhood templates (NIHPD), with the final atlas (the Edinburgh Neonatal Atlas, ENA25) constructed using iterative averaging of T1-weighted volumes. The computed transformations were applied to T2-weighted data, diffusion maps and tissue probability maps to provide a multi-modal atlas with 107 anatomical regions; and we have generated a symmetric version to facilitate studies of laterality.

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