Abstract #4422

Assessing the effects of pediatric subject motion on T2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators (vNavs)

Jeffrey N Stout¹, M. Dylan Tisdall², Patrick McDaniel³, Borjan Gagoski⁴, Divya S Bolar^2,5, Patricia Ellen Grant⁴, and Elfar Adalsteinsson^1,3,6

¹Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, ²Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Boston, MA, United States, ³Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, ⁴Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, ⁵Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, ⁶Institute for Medical Engineering and Science, Cambridge, MA, United States

When using the T₂-relaxation under spin tagging (TRUST) technique on non-compliant subjects, motion has an unknown effect on estimations of cerebral oxygenation that are derived from an empirical mapping between T₂ and blood oxygen saturation. Incorporating low resolution 3D-EPI volume navigators into the TRUST pulse sequence permits independent measurements of motion during scanning. We show that for static scans vNav modules have only small effects on resulting venous blood T₂ estimates, that poor exponential goodness of fit is not a sufficient indicator of motion, and that T₂ is biased upwards with increasing motion.

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