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Abstract #4422

Assessing the effects of pediatric subject motion on T2 relaxation under spin tagging (TRUST) cerebral oxygenation measurements using volume navigators (vNavs)

Jeffrey N Stout1, M. Dylan Tisdall2, Patrick McDaniel3, Borjan Gagoski4, Divya S Bolar2,5, Patricia Ellen Grant4, and Elfar Adalsteinsson1,3,6

1Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 2Martinos Center for Biomedical Imaging, MGH/Harvard Medical School, Boston, MA, United States, 3Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 4Fetal-Neonatal Neuroimaging and Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, 5Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 6Institute for Medical Engineering and Science, Cambridge, MA, United States

When using the T2-relaxation under spin tagging (TRUST) technique on non-compliant subjects, motion has an unknown effect on estimations of cerebral oxygenation that are derived from an empirical mapping between T2 and blood oxygen saturation. Incorporating low resolution 3D-EPI volume navigators into the TRUST pulse sequence permits independent measurements of motion during scanning. We show that for static scans vNav modules have only small effects on resulting venous blood T2 estimates, that poor exponential goodness of fit is not a sufficient indicator of motion, and that T2 is biased upwards with increasing motion.

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