Abstract #4519

Quantitative MR evaluation of fatty infiltration and edema-like processes in skeletal muscles of Myotonic Dystrophy type 1

Linda Heskamp¹, Marlies van Nimwegen², Barbara Janssen¹, Baziel van Engelen², and Arend Heerschap¹

¹Department of Radiology and Nuclear Medicine, Radboud university medical center, Nijmegen, Netherlands, ²Department of Neurology, Radboud university medical center, Nijmegen, Netherlands

We used quantitative MR to evaluate the extent of fatty infiltration and edema-like processes in muscles of patients with Myotonic Dystrophy type 1 (DM1). Fat fractions were obtained using a DIXON method and the T2 of muscle water (T2_water) was calculated using a bi-component extended phase graph model. The results show that fatty infiltration in DM1 is a slow gradual process whereby the distal part of the muscle is more heavily fat infiltrated than the proximal part. In addition, muscles that are in an active process of fatty infiltration have an elevated T2_water, possibly from reactive edema.

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