Abstract #0069

Accelerating High Resolution Hyperpolarized 13C T2 Mapping Using a Local Low Rank plus Sparse Reconstruction

Eugene Milshteyn^1,2, Galen D. Reed³, Cornelius von Morze¹, Zihan Zhu^1,2, Jeremy W. Gordon¹, and Daniel B. Vigneron^1,2

¹Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, ²UC Berkeley-UCSF Graduate Program in Bioengineering, UCSF and University of California, Berkeley, San Francisco, CA, United States, ³HeartVista Inc., Los Altos, CA, United States

Hyperpolarized ¹³C probe development has allowed in vivo monitoring of different physiological processes relating to various diseases, including cancer and diabetes. Each new probe is typically characterized with polarization and T₁ measurements, but T₂ is also an important parameter for optimal sequence design, including progressive flip angle schemes. To improve the spatiotemporal resolution of T₂ mapping sequences and subsequent multi-exponential analysis, this project investigated using a local low rank plus sparse reconstruction for 2-fold acceleration of in vivo T₂ mapping with the bSSFP sequence.

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