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Abstract #0069

Accelerating High Resolution Hyperpolarized 13C T2 Mapping Using a Local Low Rank plus Sparse Reconstruction

Eugene Milshteyn1,2, Galen D. Reed3, Cornelius von Morze1, Zihan Zhu1,2, Jeremy W. Gordon1, and Daniel B. Vigneron1,2

1Radiology and Biomedical Imaging, UCSF, San Francisco, CA, United States, 2UC Berkeley-UCSF Graduate Program in Bioengineering, UCSF and University of California, Berkeley, San Francisco, CA, United States, 3HeartVista Inc., Los Altos, CA, United States

Hyperpolarized 13C probe development has allowed in vivo monitoring of different physiological processes relating to various diseases, including cancer and diabetes. Each new probe is typically characterized with polarization and T1 measurements, but T2 is also an important parameter for optimal sequence design, including progressive flip angle schemes. To improve the spatiotemporal resolution of T2 mapping sequences and subsequent multi-exponential analysis, this project investigated using a local low rank plus sparse reconstruction for 2-fold acceleration of in vivo T2 mapping with the bSSFP sequence.

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