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Abstract #0162

Chemical Shift Imaging of pH with Hyperpolarized [2-13C,D10] Diethylmalonic Acid

David Korenchan1,2, Celine Taglang1, Cornelius von Morze1, Joseph Blecha1, Jeremy Gordon1, Peder Larson1,2, Henry VanBrocklin1, John Kurhanewicz1,2, David Wilson1, and Robert Flavell1

1Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, United States, 2Bioengineering, University of California, Berkeley, Berkeley, CA, United States

Imaging tumoral pH may aid in characterizing aggressiveness, metastasis, and therapeutic response. The study of hyperpolarized (HP) 13C chemical shift-based probes addresses some of the limitations of previously reported ratiometric methods, including HP 13C bicarbonate. We report the development of HP [2-13C,D10] diethylmalonic acid as a pH imaging agent, which exhibits a significant 13C chemical shift difference over the physiologic pH range. We demonstrate that this compound can be copolarized with tert-butanol to accurately measure pH in phantom studies. Furthermore, this HP compound showed high in vivo SNR in a murine model of prostate cancer.

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