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Abstract #0163

Long-lasting, liquid-state 13C hyperpolarization > 20 % generated in an MRI system within seconds enables fast 13C imaging

Andreas Benjamin Schmidt1, Stephan Berner1, Waldemar Schimpf1, Christoph Müller1, Thomas Lickert2, Niels Schwaderlapp1, Stephan Knecht1, Jason Skinner1, Anna Dost1, Philipp Rovedo1, Jürgen Hennig1, Dominik von Elverfeldt1, and Jan-Bernd Hövener1,3

1University Medical Center Freiburg, Freiburg, Germany, 2Fraunhofer Institute for Solar Energy Systems (ISE), Freiburg, Germany, 3German Consortium for Cancer Research (DKTK), Heidelberg, Germany

Current methods for the production of hyperpolarized 13C-tracers require a dedicated, complex and costly polarizer device. Here we present, for the first time, 13C-hyperpolarization >20% and ex-vivo 13C-MRI without an external polarizer, but by using the hardware of an MRI system instead: a simple, low-cost (≈1000€) setup was built and high-field spin-order-transfer sequences were exploited to transfer the spin-order of parahydrogen to 13C;the implementation on any multinuclear MRI system appears feasible. The tracer is produced near the application site and subsequent 13C-MRI is possible without transfer of the sample, at a fraction of the cost and complexity of external polarizers.

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