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Abstract #0182

Quality Assurance of Neuro-MRI within Multicenter Clinical Trials

Preethi Subramanian1, David P Poon1, Shivangi N Vora1, Sydney A Cearlock1, Xiangyu Yang1, Jun Zhang1, and Michael V Knopp1

1Wright Center of Innovation in Biomedical Imaging, The Ohio State University, Columbus, OH, United States

Volumetric analysis and quantification especially of dynamic MR sequences is increasingly invaluable for assessing treatment response and time to progression in the majority of clinical trials focusing on neuro-oncology. These innovative therapeutic trials rely heavily on consistent image acquisitions even in multi-center Phase 2/3 trials. We have developed a highly structured DICOM tag based, parameter driven, semi-automated QC approach that readily enables visualization of acquisition inconsistencies using a heat-mapping spectrum. As the imaging core laboratory for several NCI-NCTN clinical trials, we expanded the QC methodology to also enable constructive feedback education / training to help improve the quality of Neuro-MRI submissions.

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