Brain MR image intensities do not have a fixed tissue-specific value. Especially in longitudinal studies, where a subjects’ anatomy might change, pathology can arise, scanner software and hardware may be replaced, the resulting image intensities can differ widely. This thwarts subsequent post-processing or image analysis. Various image intensity normalization techniques exist, but are often evaluated on healthy subjects. In this work, we evaluate six normalization techniques on 25 image-pairs (five year interval) of subjects with brain pathology. Traditional methods (e.g. Gaussian and Z-Score) are clearly affected by the presence of pathology and perform less than more recent techniques.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords