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Abstract #0184

Novel Design of a 3D-Printed Anthropomorphic Brain Phantom for Segmentation Validation in Magnetic Resonance Imaging

Anna Altermatt1,2, Francesco Santini1,3, Xeni Deligianni1,3, Stefano Magon2,4, Philippe Cattin1, Jens Wuerfel1,2, and Laura Gaetano2,4

1Department of Biomedical Engineering, University Basel, Basel, Switzerland, 2Medical Image Analysis Center (MIAC) AG, Basel, Switzerland, 3Department of Radiology, University Hospital Basel, Basel, Switzerland, 4Department of Neurology, University Hospital Basel, Basel, Switzerland

Precise brain phantoms are important for evaluating the quality of segmentation tools for brain MRI. Here we suggested the construction of a 3D physical brain phantom as gold standard to validate the performance of those tools. Folding patterns of grey and white matter compartments were replicated using 3D-printed models from a real structural brain scan. T1 and T2 intensities of these brain regions in a 3 Tesla MRI were mimicked by a 0.6% agar mixture containing the appropriate concentrations of the paramagnetic compounds Ferumoxide and Manganese chloride. With its 3D-printed brain-like design, the phantom showed to be a promising alternative to existing methods for MRI segmentation validation.

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