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Abstract #0185

Traffic-Related Air Pollution Associated with Reduced Cortical Thickness and Altered White Matter Organization in a Longitudinally Studied, Pediatric Cohort

Kim M Cecil1, Travis Beckwith1, Mekibib Altaye2, Rachel Severs2, Christopher Wolfe2, Zana Percy3, Thomas Maloney1, Kimberly Yolton2, Grace LeMasters3, and Patrick Ryan2

1Radiology/Imaging Research Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 2Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, 3University of Cincinnati College of Medicine, Cincinnati, OH, United States

Traffic-related air pollution (TRAP) is strongly associated with adverse cardiopulmonary health effects. Evidence suggests the developing brain may also be a target organ for particulate matter due to translocation either from the respiratory system or through the olfactory nerve. Using a pediatric cohort, we tested the hypothesis that exposure to TRAP during critical windows of brain development is significantly associated with changes in brain structure and organization. Children with high exposure levels at time of birth were associated with reductions in brain volume, cortical thickness, and diffusion abnormalities in white matter at 12 years compared with children at low exposure.

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