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Abstract #0186

Investigating structural brain change with heart failure using voxel-based morphometry

Karsten Mueller1, Friederike Thiel1, Andrej Teren2,3, Frank Beutner2,3, Stefan Frisch4, Joachim Thiery3,5, Harald E. Möller1, Arno Villringer1,3,6, and Matthias L. Schroeter1,3,6

1Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Herzzentrum Leipzig, Leipzig, Germany, 3Leipzig Research Center for Civilization Diseases (LIFE), Leipzig, Germany, 4Department of Neurology, Center of Neurology and Neurosurgery, University Hospital Frankfurt, Frankfurt, Germany, 5Institute of Laboratory Medicine, University Hospital Leipzig, Leipzig, Germany, 6Clinic for Cognitive Neurology, University Hospital Leipzig, Leipzig, Germany

Heart failure is a multifactorial disease including a reduced pump efficiency leading to an insufficient oxygen supply for all body organs. However, the consequence of heart failure to brain structure is an important issue that needs further investigation. We used structural MRI with voxel-based morphometry to investigate a relationship between gray matter density and heart failure using ejection fraction and N-terminal prohormone of brain natriuretic peptide as markers for disease severity. These markers were found to be associated with decreased gray matter density in orbitofrontal and hippocampal brain regions indicating local gray matter abnormalities in these regions with heart failure.

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