Abstract #0351

Regionally differentiated cerebral blood flow increases during infancy measured with pCASL MRI

Qinlin Yu^1,2,3,4, Huiying Kang^1,5, Minhui Ouyang^1,2, Yun Peng⁵, Fang Fang^3,4, and Hao Huang^1,2

¹Department of Radiology, Children’s Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, ³School of Psychological and Cognitive Sciences, Peking University, Beijing, People's Republic of China, ⁴Peking-Tsinghua Center for Life Science, Peking University, Beijing, People's Republic of China, ⁵Department of Radiology, Beijing Children’s Hospital, Capital Medical University, Beijing, People's Republic of China

During infant brain development, rapid neuronal growth requires increases of cerebral blood flow. In this study, we quantified cerebral blood flow (CBF) at regional level during infant development by using pseudo-continuous arterial spin labeled (pCASL) perfusion MRI. The CBF maps at different infant stages from 0 to 24 months were revealed. The trend lines of CBF at specific regions were charted. It has been found that the CBF increases linearly at different brain regions, with CBF increasing faster in visual, posterior cingulate, medial prefrontal and inferior parietal cortex than whole brain.

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