Abstract #0367

Determining the T1 of the water in the liver by modelling the effects of fat, iron and off-resonance frequencies on MOLLI T1 measurements

Ferenc Emil Mozes¹, Elizabeth Mary Tunnicliffe¹, Thomas Marjot², Christina Kim Levick^1,3, Michael Pavlides^1,3, and Matthew David Robson¹

¹University of Oxford Centre for Magnetic Resonance Research, University of Oxford, Oxford, United Kingdom, ²Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, United Kingdom, ³Translational Gastroenterology Unit, University of Oxford, Oxford, United Kingdom

The frequency dependence of balanced steady-state free precession signals causes significant alterations in modified Look-Locker inversion recovery T1 measurements of livers with fat accumulation, leading to either under- or over-estimation of liver T1 values. This is further to the already-known influence of iron. The present study shows a possibility to correct for these effects, yielding a T1 measurement that represents the T1 of the water component independent of the fat and is tested both in phantoms and human participants.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.