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Abstract #0530

Quantification of Perfusion in Hypertrophic Cardiomyopathy using 3D Contrast Agent Flow Simulation

Leili Riazy1, Marc Olbrich2, Tobias Schaeffter3, Simone Fritschi4,5, Thoralf Niendorf1, and Jeanette Schulz-Menger4,5

1Berlin Ultrahigh Field Facility (B.U.F.F.), Max-Delbrueck Center for Molecular Medicine, Berlin, Germany, 2Technical University Berlin, Berlin, Germany, 3Medical Physics and Metrological Information Technology, Physikalisch-Technische Bundesanstalt, Berlin, Germany, 4Working Group on Cardiovascular Magnetic Resonance, Experimental and Clinical Research Center (ECRC), Berlin, Germany, 5Department of Cardiology and Nephrology, HELIOS Klinikum Berlin Buch, Berlin, Germany

Hypertrophic Cardiomyopathy (HCM) is a common cause of sudden heart death in young adults. MRI is a powerful tool for the diagnosis and surveillance of this myocardial morphology as well as tissue injury. In clinical routine the assessment is mainly based on visual assessment or semi-quantification is increasingly used. Quantification of perfusion defect should be nowadays assessed with computational tools. We aim at quantifying differences in perfusion with a computational flow model that incorporates the vascular, as well as extracellular compartment, using the Damköhler Number $$$Da$$$. Areas of different perfusion in N=5 patients with HCM were fitted in $$$Da$$$ with model-derived curves with an overall error of 10.48%.

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