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Abstract #0531

Intravoxel Incoherent Motion Model in the Heart of Patients under Adenosine Induced Stress

Georg Spinner1, Constantin von Deuster1, Sabrina Oebel2, Christian Torben Stoeck1, Robert Manka2, and Sebastian Kozerke1

1Institute for Biomedical Engineering, ETH Zürich, Zürich, Switzerland, 2Cardiology, University Hospital Zürich

Intravoxel Incoherent Motion Imaging (IVIM) in the in vivo human heart has the potential of measuring myocardial perfusion without the need for contrast agents. In order to validate previous IVIM animal studies, patients where measured both during rest and under adenosine induced stress using a slice following second-order motion compensated diffusion weighted imaging sequence. The IVIM perfusion fraction is found to significantly increase during stress, which shows that IVIM imaging allows measuring a perfusion surrogate. This can hence be used for example to assess perfusion deficits in patients with ischemia.

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