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Abstract #0669

Deep learning to improve prostate cancer diagnosis

Nikolaos Dikaios1, Edward W Johnston2, Harbir S Sidhu2, Mrishta B Appaya2, Alex Freeman3, Hashim U Ahmed4, and Shonit Punwani2

1Electrical Engineering, University of Surrey, Guildford, United Kingdom, 2Centre for Medical Imaging, University College London, 3Histopathology, University College London, 4Surgery and Interventional Science, University College London

Multiparametric MRI (mp-MRI) can localize tumour within the prostate, guide biopsy, and assess disease burden. Nevertheless, mp-MRI itself remains imperfect. Almost 40% of mp-MRI studies are reported as indeterminate for significant cancer. An indeterminate mp-MRI confers no patient benefit, such patients require either repeat interval mp-MRI and/or subsequent biopsy. There remains a clear unmet need to improve diagnostic imaging over and above standard mp-MRI protocols. Previous work has developed zone specific logistic regression (LR) models for the determination of significant cancer (any cancer-core-length (CCL) with Gleason>3+3 or any grade with CCL≥4 mm) in the peripheral (PZ) and the transition zone (TZ) based on quantitative mp-MRI parameters following MR imaging. This work proposes a state-of-art deep learning method to detect prostate cancer both in the PZ and the TZ. The proposed model is trained on a cohort of patients imaged at a 3T scanner, and validated on independent cohort of patients imaged at a 1.5T scanner. The performance of the model was compared with LR, Support Vector Machines and traditional Neural Networks.

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