Coronary Plaque Hyper-Intensity on Dark-Blood T1-Weighted MRI Helps Identify Lesion-Specific Ischemia: Insights from the Comparison Study with Invasive Fractional Flow Reserve (FFR)
Yibin Xie1, Young-Jin Kim2, Sang-Eun Lee3, Jianing Pang4, Anthony Christodoulou1, Qi Yang1, Zixin Deng1, Daniel Berman5, Hyuk-Jae Chang3, and Debiao Li1
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Siemens Healthcare, Chicago, IL, United States, 5Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States
Coronary Atherosclerosis T1-weighted Characterization (CATCH) is an accelerated MR technique for detecting high-risk atherosclerotic lesions. However, the relationship between plaque signal and lesion-specific ischemia is still unclear. In this study we applied CATCH in a patient cohort undergoing invasive FFR and discovered the association between plaque hyper-intensity and hemodynamic functional significance. The results presented here support the potential clinical utility and added value of MR coronary plaque characterization as a “gate-keeper” for invasive and costly coronary procedures.
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