Abstract #0797

Coronary Plaque Hyper-Intensity on Dark-Blood T1-Weighted MRI Helps Identify Lesion-Specific Ischemia: Insights from the Comparison Study with Invasive Fractional Flow Reserve (FFR)

Yibin Xie¹, Young-Jin Kim², Sang-Eun Lee³, Jianing Pang⁴, Anthony Christodoulou¹, Qi Yang¹, Zixin Deng¹, Daniel Berman⁵, Hyuk-Jae Chang³, and Debiao Li¹

¹Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, ²Department of Radiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Seoul, Korea, Republic of, ⁴Siemens Healthcare, Chicago, IL, United States, ⁵Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Coronary Atherosclerosis T1-weighted Characterization (CATCH) is an accelerated MR technique for detecting high-risk atherosclerotic lesions. However, the relationship between plaque signal and lesion-specific ischemia is still unclear. In this study we applied CATCH in a patient cohort undergoing invasive FFR and discovered the association between plaque hyper-intensity and hemodynamic functional significance. The results presented here support the potential clinical utility and added value of MR coronary plaque characterization as a “gate-keeper” for invasive and costly coronary procedures.

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