Abstract #0798

Multi-contrast Acquisition in a Single Scan (MASS) for Three-dimensional Quantitative T1 Mapping of Carotid Atherosclerosis

Haikun Qi¹, Huiyu Qiao¹, Shuo Chen¹, Zechen Zhou², Xinlei Pan¹, Yishi Wang¹, Chun Yuan^1,3, and Huijun Chen¹

¹Center for Biomedical Imaging Research, School of Medicine, Tsinghua University, Beijing, People's Republic of China, ²Philips Research China, Shanghai, People's Republic of China, ³Department of Radiology, University of Washington School of Medicine, Seattle, WA, United States

Intra-plaque hemorrhage (IPH) is a dynamic process and change of the IPH MR signal was found to be correlated with plaque developments. So quantitative T1 mapping of plaque is essential to monitor plaque progression. In this study, we proposed an IR prepared 3D golden angle radial sampling sequence, enabling multiple T1 contrasts acquisition in a single scan (MASS) with application to carotid artery T1 mapping. The accuracy and feasibility of MASS was demonstrated in phantom studies and in vivo imaging experiments on healthy volunteers and carotid atherosclerosis patients. MASS may be a one-stop solution to carotid atherosclerotic plaque imaging.

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