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Abstract #0979

Feasibility of magnetic resonance colonography for an immune check-point inhibitor in orthotopic colorectal rechallenge tumor models

Jinil Kim1, Yoon Seok Choi2, Dong-Cheol Woo1, Chul-Woong Woo1, Sang Tae Kim1, Jae Im Kwon1, and Kyung Won Kim3

1Asan Institute for Life Sciences, ASAN Medical Center, Seoul, Korea, Republic of, 2Medical research institute, Gangneung Asan Hospital, Gangneung, Korea, Republic of, 3Department of Radiology, ASAN Medical Center, Seoul, Korea, Republic of

In the immunotherapy research field, establishing appropriate preclinical model is very important to evaluate the complex immune reaction. Orthotopic tumor model is more physiologic than ectopic tumor model, however its use may be limited due to difficulty in evaluating deep-seated tumors, especially in the colorectum having a complex anatomy. MR colonography (MRC) is a new technique in preclinical trial, which uses Fluorinert, a negative contrast agent, to fill the colorectum. Our study demonstrated that MRC is quite feasible to evaluate colorectal tumors and metastatic foci in orthotopic colorectal tumor model, which can be useful in immunotherapy drug development.

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