In the immunotherapy research field, establishing appropriate preclinical model is very important to evaluate the complex immune reaction. Orthotopic tumor model is more physiologic than ectopic tumor model, however its use may be limited due to difficulty in evaluating deep-seated tumors, especially in the colorectum having a complex anatomy. MR colonography (MRC) is a new technique in preclinical trial, which uses Fluorinert, a negative contrast agent, to fill the colorectum. Our study demonstrated that MRC is quite feasible to evaluate colorectal tumors and metastatic foci in orthotopic colorectal tumor model, which can be useful in immunotherapy drug development.
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