Abstract #0980

Multi-modal and multi-scale measurement of metabolism in vivo in a breast cancer model

Benjamin L Cox^1,2,3, Joseph M Szulczewski^3,4, David R Inman⁴, Erin B Adamson¹, Kai D Ludwig¹, Justin J Jeffery⁵, Stephen A Graves¹, Alison B Roth¹, David B Mummy^1,6, Patricia J Keely⁴, Kevin W Eliceiri^1,2,3,5,6, and Sean B Fain^1,7

¹Medical Physics, University of Wisconsin - Madison, Madison, WI, United States, ²Medical Engineering, Morgridge Institute for Research, Madison, WI, United States, ³Laboratory for Optical and Computational Instrumentation (LOCI), University of Wisconsin - Madison, Madison, WI, United States, ⁴Cell and Regenerative Biology, University of Wisconsin - Madison, Madison, WI, United States, ⁵UW Carbone Cancer Center, Madison, WI, United States, ⁶Biomedical Engineering, University of Wisconsin - Madison, Madison, WI, United States, ⁷Radiology, University of Wisconsin - Madison, Madison, WI, United States

Performing MRI, PET/CT, and optical imaging at the cellular scale in vivo provides highly complementary information as a powerful tool to study cancer metabolism. Recent development of implanted optical windows allows for optical imaging in vivo. Here, we demonstrate multi-modal and multi-scale imaging of tumor progression in a mouse model of breast cancer by performing optical imaging through an implanted window, and whole-body MRI and PET/CT in a single day. The challenge of PET-MR registration is also addressed using dual-PET-MR fiducial markers embedded in a custom-imaging tray.

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