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Abstract #0981

Dynamic Glucose Enhanced MRI - A prospective study in healthy volunteers and glioblastoma patients

Daniel Paech1, Patrick Schuenke2, Christina Koehler1, Johannes Windschuh2, Sibu Mundiyanapurath3, Sebastian Bickelhaupt1, Philipp Bäumer1, David Bonekamp1, Martin Bendszus4, Wolfgang Wick3, Peter Bachert2, Mark E. Ladd2, Heinz-Peter Schlemmer1, Moritz Zaiss5, and Alexander Radbruch1

1Radiology, German Cancer Research Center, Heidelberg, Germany, 2Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, 3Neurology, University Hospital Heidelberg, Heidelberg, 4Neuroradiology, University Hospital Heidelberg, Heidelberg, 5Max-Planck-Institut Tübingen, Tübingen, Germany

Glucose is the main energy source of cancer cells to proliferate and survive. Recently, promising results to assess changes in cellular metabolism using natural unlabeled D-glucose as biodegradable MRI contrast agent, have been reported employing Chemical Exchange Saturation Transfer (CEST) and Chemical Exchange sensitive Spin-Lock (CESL) imaging. In this work, the CESL-based dynamic glucose enhanced (DGE) contrast was investigated in healthy volunteers and a homogenous cohort of newly diagnosed untreated glioblastoma patients at 7 Tesla. DGE MRI allowed for sensitive visualization of physiological glucose uptake in the healthy human brain and pathophysiologically increased glucose enhancement of brain tumors.

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