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Abstract #1072

Dynamic Contrast-Enhanced Magnetic Resonance Imaging: A Pre-Clinical Approach to Detect and Monitor Diabetes

Dorela Doris Shuboni-Mulligan1, Christiane L Mallett2, Maciek Parys3, Barbara Blanco-Fernandez4, and Erik M Shapiro1

1Radiology, Michigan State University, East Lansing, MI, United States, 2Radiology, Michigan State University, East Lansing, MI, 3Department of Comparative Medicine and Integrative Biology Program, Michigan State University, East Lansing, MI, United States, 4Radiology, East Lansing, MI, United States

The link between diabetes and dysregulation of OATP transporters provides an avenue for imaging the disease with MRI. The aim of this work was to use DCE-MRI to non-invasively measure decreases of OATPs during the onset of diabetes. The data presented here verifies that both Gd-EOB-DTPA and Gd-BOPTA enhanced MRI reveals underlying alterations in OATPs that are present in the liver and kidney as a result of diabetes. Preliminary data further suggests that there could be a link between changes in organ enhancement and disease onset. Thus, there is the potential to monitor diabetes and perhaps even diagnose pre-diabetes.

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